HealthDay News — There is underrepresentation of racial/ethnic minorities and older patients amongst U.S.-primarily based vaccine clinical trials, although female adults are overrepresented, according to a study published on line Feb. 19 in JAMA Network Open.
Laura E. Flores, from the University of Nebraska Medical Center in Omaha, and colleagues examined regardless of whether racial and/or ethnic minorities, ladies, and older adults have been underrepresented in vaccine clinical trials completed among July 1, 2011, and June 30, 2020. Data have been integrated for 230 U.S.-primarily based trials with 219,555 participants.
The researchers discovered that compared with U.S. census information, White persons have been overrepresented (77.9 %), Black/African Americans and American Indian/Alaska Natives have been underrepresented (10.6 and .4 %, respectively), and Asian enrollment appeared to be equally represented (5.7 %). Among the restricted quantity of adult trials reporting ethnicity (34.3 %), Hispanic enrollment was low (11.6 %). Female participants have been a majority (56 %) in adult trials. For trials reporting age as a percentage, enrollment of participants aged 65 years or older was low at 12.1 %. In pediatric trials, Black/African American and Hispanic participants have been underrepresented (10.1 and 22.5 %, respectively). Overall, 48.5 and 60.4 % of these trials reporting race/ethnicity did not involve American Indian/Alaska Native or Hawaiian/Pacific Islander participants, respectively.
“Although we have some missing data, it is clear from the large number of studies which did report this information, that racial and ethnic minorities as well as older individuals are frequently not being equitably represented,” a coauthor mentioned in a statement.
One author disclosed monetary ties to the biopharmaceutical sector.
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