Patients who are newly diagnosed with obsessive-compulsive disorder (OCD), even in the absence of psychiatric drug use, are at elevated danger for dry eye disease (DED), according to analysis published in Cornea.
Researchers carried out a potential study to evaluate the association involving newly-diagnosed OCD and DED in 30 remedy-naive patients with OCD and 30 healthier controls wherein researchers obtained the Ocular Surface Disease Index (OSDI) values, tear breakup time, Schirmer I test, corneal and conjunctival staining grade, and neutrophil-to-leucocyte values for all participants.
In the patients with an OCD diagnosis, the study located drastically greater values in OSDI (P =.001), corneal Oxford scoring (P =.02), and conjunctival Oxford scoring (P =.04), with regularly reduced values in the Schirmer I test (P =.043) and tear breakup time (TBUT) (P =.001). Also, imply neutrophil-to-leukocyte ratio values had been drastically greater in the OCD group compared with controls (P =.001).
The researchers note that these findings recommend inflammation may perhaps be partially accountable for this partnership. Another contributing element, they clarify, could be neurological.
“In addition to the inflammatory process, it has been found that neurotransmitter dysregulation, particularly serotonin, may contribute to the pathogenesis of OCD,” the study explains. “It has been postulated that disturbances in the serotonin neurotransmitter system may affect the meibomian glands and cause tear film deficiency in depressive patients.”
The study elaborates on this point, pointing out that especially, this neurological reaction may perhaps lead to modifications in the composition of tears, improved Oxford rating, and a decreased TBUT.
Finally, the researchers make clear that, while OSDI values for OCD patients (imply = 30.8) had been drastically greater than these of manage patients (imply = 20.8), this element alone was not sufficient to constitute DED in the OCD group.
“Interestingly, although all objective dry eye parameters were worse in patients with OCD compared with the control group, none of them was sufficient to diagnose dry eye, except for TBUT,” the study explains.
Eroglu FC, Gediz BS, Ozturk M, Kazancı B. Association between dry eye disease and newly diagnosed obsessive-compulsive disorder. Cornea. 202140(7):817-821. doi:10.1097/ICO.0000000000002724.
This report initially appeared on Ophthalmology Advisor